André Boonstra, PhD
Assistant Professor

Contact details:
Room L-455

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André Boonstra studied Biology at the University of Groningen, the Netherlands (1988-1993). After receiving his degree he worked at the National Institute for Public Health and the Environment (RIVM), the Netherlands, and started his PhD project in 1996 at the Department of Immunology of the Erasmus MC in Rotterdam. During his PhD period he visited DNAX Research Institute, USA to study the development of regulatory T cells. He succesfully defended his thesis entitled "Modulation of T helper cell activity by ultraviolet B irradiation -analysis of cytokines and genetic susceptibility factors" in 2000, and returned to DNAX Research Institute, USA, as a post-doctoral fellow to study the function of myeloid and plasmacytoid dendritic cells and their effect on Th cell development. In 2002, he moved to the National Institute for Medical Research, London, UK, to focus on the immunology of Mycobacterium tuberculosis infections. In September 2006 he became a staff member at the Department of Gastroenterology and Hepatology of the Erasmus MC in Rotterdam, The Netherlands, where he focuses on the immunology of hepatitis C virus infections.

Selected references:

• Claassen MAA, de Knegt RJ, Turgut D, Tilanus HW, Janssen HLA, Boonstra A.
  Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis.
  J Hepatol. 2010. 52(3):315-21
  
• Boonstra A, van der Laan LJW, Vanwolleghem T, Janssen HLA.
  Experimental models for hepatitis C viral infection.
  Hepatology. 2009. 50: 1646-1655.
  
• Liu B, Woltman AM, Janssen HLA, Boonstra A.
  Modulation of dendritic cell function by persistent viruses.
  J Leukoc Biol. 2009. 85: 205-214.
  
• Boonstra A, Asselin-Paturel C, Gilliet M, Crain C, Trinchieri G, Liu Y-J, O'Garra A.
  Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential Toll-like receptor ligation.
  J Exp Med. 2003. 197: 101-109.
  
• Asselin-Paturel C, Boonstra A, Dalod M, Durand I, Yessaad N, Dezutter-Dambuyant C, Vicari A, O'Garra A, Biron C, Brière F, Trinchieri G.
  The major type I interferon producing cells in the mouse are immature antigen-presenting cells exhibiting plasmacytoid morphology.
  Nature Immunol. 2001. 2: 1144-1150.

Do a PubMed search for references by André Boonstra.

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