Jaap Kwekkeboom, PhD
Assistant Professor

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Room L-455

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Curriculum Vitae Jaap Kwekkeboom, PhD

• Date of birth: 9-5-1959 (Aagtekerke, The Netherlands)


• Male, married, 4 children (born 1987, 1988, 1991, 1995)


• MSc: Medical Biology, University of Utrecht in 1977-1984


• PhD: cell biology, Gaubius Laboratory, Netherlands Organization for Applied Research (TNO) in Leiden. Thesis: "Regulation of bile acid synthesis in cultured hepatocytes", University of Leiden, 12-4-1990


• Postdoc: cellular immunology, Department of Cell Biology and Histology, Academic Medical Centre, Amsterdam; 1990 - 1993


• Postdoc: hematopoietic stem cell transplantation, Sanquin/CLB Research, Amsterdam; 1993-1996)


• Assistant professor: liver transplant immunology, Department of Internal Medicine II, Erasmus MC, Rotterdam (1997-2000)


• Asistent professor and staff member, Department of Gastroenterology and Hepatology, Erasmus MC (from 2000). Main research subject: liver (transplant) immunology


• Deputy Head Laboratory of Gastroenterology and Hepatology Erasmus MC (2008-2009)


• Board member Dutch Society for Hepatology (2001-2009)

Selected references:

• Moroso V, Famili F, Papazian N, Cupedo T, van der Laan LJ, Kazemier G, Metselaar HJ, Kwekkeboom J.
  NK cells can generate from precursors in the adult human liver.
  Eur J Immunol 2011;41(11): 3340-3350.
• Boor PP, Metselaar HJ, Jonge S, Mancham S, van der Laan LJ, Kwekkeboom J.
  Human plasmacytoid dendritic cells induce CD8 LAG-3 Foxp3 CTLA-4 regulatory T cells that suppress allo-reactive memory T cells.
  Eur J Immunol 2011;41(6): 1663-1674.
• Tapirdamaz O, Mancham S, van der Laan LJ, Kazemier G, Thielemans K, Metselaar HJ, Kwekkeboom J.
  Detailed kinetics of the direct allo-response in human liver transplant recipients: new insights from an optimized assay.
  PLoS One 2010;5(12): e14452.
• Tha-In, T., J. Bayry, H. J. Metselaar, S. V. Kaveri, and J. Kwekkeboom.
  Modulation of the cellular immune system by intravenous immunoglobulin.
  Trends in immunology 29:608-615 (2008)


• Tha-In, T., H. J. Metselaar, H. W. Tilanus, Z. M. Groothuismink, E. J. Kuipers, R. A. de Man, and J. Kwekkeboom.
  Intravenous immunoglobulins suppress T-cell priming by modulating the bidirectional interaction between dendritic cells and natural killer cells.
  Blood 110:3253-3262 (2007)


• Demirkiran, A., B. M. Bosma, A. Kok, C. C. Baan, H. J. Metselaar, J. N. Ijzermans, H. W. Tilanus, J. Kwekkeboom, and L. J. van der Laan.
  Allosuppressive donor CD4+CD25+ regulatory T cells detach from the graft and circulate in recipients after liver transplantation.
  J Immunol 178:6066-6072 (2007)


• Tapirdamaz, O., V. Pravica, H. J. Metselaar, B. Hansen, L. Moons, J. B. van Meurs, I. V. Hutchinson, J. Shaw, K. Agarwal, D. H. Adams, C. P. Day, and J. Kwekkeboom.
  Polymorphisms in the T cell regulatory gene cytotoxic T lymphocyte antigen 4 influence the rate of acute rejection after liver transplantation.
  Gut 55:863-868 (2006)
  
• Boor, P. P., H. J. Metselaar, S. Mancham, H. W. Tilanus, J. G. Kusters, and J. Kwekkeboom.
  Prednisolone suppresses the function and promotes apoptosis of plasmacytoid dendritic cells.
  Am J Transplant 6:2332-2341. (2006)
• Tang, T. J., J. Kwekkeboom, S. Mancham, R. S. Binda, R. A. de Man, S. W. Schalm, J. G. Kusters, and H. L. Janssen.
  Intrahepatic CD8+ T-lymphocyte response is important for therapy-induced viral clearance in chronic hepatitis B infection.
  J Hepatol 43:45-52 (2005)
• Kwekkeboom, J., T. Tha-In, W. M. Tra, W. Hop, P. P. Boor, S. Mancham, P. E. Zondervan, A. C. Vossen, J. G. Kusters, R. A. de Man, and H. J. Metselaar.
  Hepatitis B immunoglobulins inhibit dendritic cells and T cells and protect against acute rejection after liver transplantation.
  Am J Transplant 5:2393-2402 (2005)
• van der Molen, R. G., D. Sprengers, R. S. Binda, E. C. de Jong, H. G. Niesters, J. G. Kusters, J. Kwekkeboom, and H. L. Janssen.
  Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B.
  Hepatology 40:738-746 (2004)
• Kwekkeboom, J., P. E. Zondervan, M. A. Kuijpers, H. W. Tilanus, and H. J. Metselaar.
  Fine-needle aspiration cytology in the diagnosis of acute rejection after liver transplantation.
  Br J Surg 90:246-247 (2003)
• de Reuver, P., V. Pravica, W. Hop, P. Boor, H. J. Metselaar, I. V. Hutchinson, H. W. Tilanus, and J. Kwekkeboom.
  Recipient ctla-4 +49 G/G genotype is associated with reduced incidence of acute rejection after liver transplantation.
  Am J Transplant 3:1587-1594 (2003)
• Kwekkeboom, J., D. E. Buurman, R. E. Ploemacher, J. W. Baars, H. A. Loos, and I. C. Slaper-Cortenbach.
  A nylon wool filter coated with human immunoglobulin for rapid depletion of monocytes and myeloid cells from peripheral blood stem cell transplants.
  Exp Hematol 26:400-408 (1998)
• Kwekkeboom, J., D. de Rijk, A. Kasran, S. Barcy, C. de Groot, and M. de Boer.
  Helper effector function of human T cells stimulated by anti-CD3 mAb can be enhanced by co-stimulatory signals and is partially dependent on CD40-CD40 ligand interaction.
  Eur J Immunol 24:508-517 (1994)
• Kwekkeboom, J., H. M. Princen, E. M. van Voorthuizen, and H. J. Kempen.
  Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7 alpha-hydroxylase activity.
  Hepatology 12:1209-1215 (1990)

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