Andrea M. Woltman, PhD
Assistant Professor

Contact details:
Room L-458

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Andrea Woltman studied Biomedical Sciences at the University of Leiden, The Netherlands (1993-1998). She performed her Ph.D. study at the Department of Nephrology of the Leiden University Medical Center in Leiden with a research visit to Schering-Plough, Dardilly, France. She successfully defended her thesis entitled "Functional modulation of human dendritic cells; immunosuppressive drugs and inflammatory mediators in renal allograft rejection" in 2002. She continued her research at the Department of Nephrology and focussed on dendritic cells as potential tools and targets to prevent renal allograft rejection. In 2005 she received a Veni (ZonMW) to work on the molecular mechanisms regulating human dendritic cell development and survival. In May 2006, she became staff member at the Department of Gastroenterology and Hepatology of the Erasmus MC in Rotterdam, The Netherlands, working on the immunology and immunopathogenesis of viral hepatitis.

Selected references:

• Tjwa ETTL, Van Oord GW, Hegmans JP, Janssen HLA, Woltman AM.
  Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B.
  J. Hepatol. In press
• van de Laar L, Buitenhuis M, Wensveen FM, Janssen HL, Coffer PJ, Woltman AM (2010).
  Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling.
  J Immunol. 184(12):6600-11.
• Woltman AM, Boonstra A, Janssen HLA. (2010).
  Dendritic cells in chronic viral hepatitis B and C: victims or guardian angels?
  Gut. 59(1):115-25. Review
• Stoop JN, Woltman AM, Biesta PJ, Kusters JG, Kuipers EJ, Janssen HL, van der Molen RG (2007).
  Tumor necrosis factor alpha inhibits the suppressive effect of regulatory T cells on the hepatitis B virus-specific immune response.
  Hepatology.46(3):699-705.
• Woltman AM, de Fijter JW, Zuidwijk K, Vlug AG, Bajema IM, van der Kooij SW, van Ham V, van Kooten C (2007).
  Quantification of dendritic cell subsets in human renal tissue under normal and pathological conditions.
  Kidney Int. 71(10):1001-8.
  
• Woltman AM, van der Kooij SW, Coffer PJ, Offringa R, Daha MR, van Kooten C (2003).
  Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression.
  Blood 101, 1439-1445.
  
• Woltman AM, de Fijter JW, Kamerling SW, van Der Kooij SW, Paul LC, Daha MR, van Kooten C (2001).
  Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages.
  Blood. 98(1):174-80.
  
  

Do a PubMed search for references by Andrea Woltman.

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