Publications of members of the Laboratory of Gastroenterology and Hepatology

In press
2011
2010
2009
2008
2007
2006
2005
2004
2003
2002
2001

In press

• Bergmann JF, de Bruijne J, Hotho DM, de Knegt RJ, Boonstra A, Weegink CJ, van Vliet AA, van de Wetering J, Fletcher SP, Bauman LA, Rahimy M, Appleman JR, Freddo JL, Reesink RW, Janssen HLA.
  Antiviral activity of ANA773, an oral inducer of endogenous interferons that acts via TLR7, in chronic hepatitis C patients.
  Alim Pharm Ther.
• Boonstra A, B-S. Liu, Z.M.A. Groothuismink, J.F. Bergmann, J. de Bruijne, D.M. Hotho, B. Hansen, A.A. van Vliet, J. van de Wetering, S.P. Fletcher, L.A. Bauman, M. Rahimy, J.R. Appleman, J.L. Freddo, H.W. Reesink,
  R.J. de Knegt, H.L.A. Janssen.
  Potent immune activation in chronic hepatitis C patients upon administration of an oral inducer of endogenous interferons that acts via TLR7.
  Antiviral Therapy.
• P.P.C. Boor, HJ. Metselaar, S. de Jonge, S. Mancham, L. J.W. van der Laan, and J. Kwekkeboom
  Human plasmacytoid dendritic cells induce CD8+LAG-3+Foxp3+CTLA-4+ regulatory T cells that suppress allo-reactive memory T cells
  Eur. J. Immunol.
• Braat H, Bruno M, Kuipers EJ, Peppelenbosch MP.
  Pancreatic Cancer: Promise for Personalized Medicine?
  Cancer Lett. 2011
• Deuring JJ, de Haar C, Koelewijn CL, Kuipers EJ, Peppelenbosch MP, van der Woude CJ.
  Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding.
  Biochem J.
• Huibregtse IL, Zaat SA, Kapsenberg ML, Sartori da Silva MA, Peppelenbosch MP, van Deventer SJ, Braat H.
  Genetically Modified Lactococcus lactis for Delivery of Human Interleukin-10 to Dendritic Cells
  Gastroenterol Res Pract.
• Li Y, de Haar C, Peppelenbosch MP, van der Woude CJ.
  New insights into the role of STAT3 in IBD
  Inflamm Bowel Dis.
• Lilian A. Curvelo, Emmeloes de Mare-Bredemeijer, Ilse de Canck, Martine van Thielen, Geert Kazemier, Herold Metselaar, Jaap Kwekkeboom.
  Does donor mannose-binding lectin genotype really predict the risk of bacterial infections after liver transplantation?
  Hepatology
• W.R.R. Farid, Q. Pan, A.J.P. van der Meer, P.E. de Ruiter, V. Ramakrishnaiah, J. de Jonge, J. Kwekkeboom, H.L.A. Janssen, H.J. Metselaar, H.W. Tilanus, G. Kazemier and L.J.W. van der Laan
  Hepatocyte-derived MicroRNAs as Serum Biomarker of Hepatic Injury and Rejection after Liver Transplantation.
  Liver Transplantation
• Viviana Moroso, Farbod Famili, Natalie Papazian, Tom Cupedo, Luc J.W. van der Laan, Geert Kazemier, Herold J. Metselaar, Jaap Kwekkeboom.
  NK cells can generate from precursors in the adult human liver
  European Journal of Immunology
• Peng C, Liu B-S, de Knegt RJ, Janssen HLA, Boonstra A.
  The response to TLR ligation of human CD16+CD14- monocytes is weakly modulated as a consequence of persistent infection with the hepatitis C virus.
  Molecular Immunology.
• Pan Q, Tilanus HW, Janssen HL, van der Laan LJ.
  Ribavirin enhances interferon-stimulated gene transcription by activation of the interferon-stimulated response element.
  Hepatology.
• Pan Q, de Ruiter PE, Metselaar HJ, Kwekkeboom J, de Jonge J, Tilanus HW, Janssen HLA and van der Laan LJW
  Mycophenolic acid augments interferon-stimulated gene expression and inhibits hepatitis C virus infection in vitro and in vivo.
  Hepatology
• Qiuwei Pan, Vedashree Ramakrishnaiah, Scot Henry, Suomi Fouraschen, Jaap Kwekkeboom, Hugo W. Tilanus, Harry L.A. Janssen and Luc J.W. van der Laan.
  Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNAi
  Gut
• Qiuwei Pan, Petra E. de Ruiter, Karin J. von Eije, Ron Smits, Hugo W. Tilanus, Harry L.A. Janssen, Ben Berkhout and Luc J.W. van der Laan
  Disturbance of the microRNA pathway by commonly used lentiviral shRNA libraries limits the application for screening host factors involved in hepatitis C virus infection
  FEBS Letter
• Qiuwei Pan, Hugo W. Tilanus, Harry L.A. Janssen and Luc J.W. van der Laan
  Ribavirin Enhances Interferon-Stimulated Gene Transcription by Activation of the ISRE Promoter Element
  Hepatology
• Roomer R, Bergmann JF, Boonstra A, Hansen BE, Haagmans B, Kwadijk-de Gijsel S, van Vuuren AJ, de Knegt RJ, Janssen HLA.
  Continuous interferon alfa-2b infusion in combination with ribavirin for chronic hepatitis c in treatment experienced patients.
  Antiviral Therapy.
• Scot Henry, Qiuwei Pan and Luc J.W. van der Laan
  Production of multicopy shRNA lentiviral vectors for antiviral therapy.
  Book chapter in “Antiviral RNAi: Immune defense and therapy” Edited by: Ronald van Rij Humana Press ISBNxxxxxxx
  
• Sint Nicolaas J, Tjon SWA, Metselaar HJ, Kuipers EJ, de Man RA, van Leerdam ME.
  Colorectal cancer in post liver transplant recipients
  Diseases of the Colon & Rectum
• Shi CC, Tjwa ETTL, Biesta PJ, Boonstra A, Xie Q, Janssen HLA, Woltman AM.
  Hepatitis B virus suppresses the functional interaction between natural killer cells and plasmacytoid dendritic cells.
  J Vir Hepatitis.
• Somasundaram R, Deuring JJ, van der Woude CJ, Peppelenbosch MP, Fuhler GM.
  Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease.
  Gut.
• Tjwa ETTL, Van Oord GW, Hegmans JP, Janssen HLA, Woltman AM.
  Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B.
  J. Hepatol.
• van de Winkel A., van Zoest K.P.M. , van Dekken H., Moons L.M.G., Kuipers E.J. and van der Laan L.J.W.
  Differential expression of the nuclear receptors FXR and PXR for grading dysplasia in patients with Barrett’s oesophagus.
  Histopathology
• Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A, Smits R, Oda N, Fodde R, Itoh M, Senda T.
  The C-terminal domain of the adenomatous polyposis coli (APC) protein is involved in thyroid morphogenesis and function
  Med. Mol. Morphol.
• Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A, Smits R, Fodde R, Itoh M, Senda T.
  Some fine-structural findings on the thyroid gland in Apc1638T/1638T mice that express a C-terminus lacking truncated Apc.
  Med. Mol. Morphol.
• Anouk van de Winkel, Vivianda Menke, Astrid Capello, Leon M.G. Moons, Raymond G.J. Pot, Herman van Dekken, Peter D. Siersema, Johannes G. Kusters, Luc J. W. van der Laan and Ernst J. Kuipers
  Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma.
  BMC Gastroenterol.
• van de Winkel A, Massl R, Kuipers EJ, van der Laan LJW and Peppelenbosch MP
  "Digestive Disease Week 2011: Highlights of clinical and preclinical research on Barrett's esophagus and associated esophageal adenocarcinoma"
  Diseases of the Esophagus

2011

• Claassen MAA, de Knegt, RJ, Janssen HLA, Boonstra A.
  Retention of CD4+CD25+FoxP3+ regulatory T cells in the liver after therapy-induced hepatitis C virus eradication in humans.
  Journal of Virology 85(11): 5323-30.

• Deuring JJ, Peppelenbosch MP, Kuipers EJ, van der Woude CJ, de Haar C
  Impeded protein folding and function in active inflammatory bowel disease.
  Biochem Soc Trans. Aug;39(4):1107-11.

• Fuhler GM, Diks SH, Peppelenbosch MP, Kerr WG
  Widespread Deregulation of Phosphorylation Based Signaling Pathways in Multiple Myeloma Cells: Opportunities for Therapeutic Intervention
  Mol Med. 2011 Apr 28. doi: 10.2119/molmed.2011.00013

• Grotenhuis BA, Franken PF, Swinkels WJC, Boonstra A, van der Valk MA, van Lanschot JJB, Fodde R.
  Early morbidity encountered in the dietary-related mouse model of Barrett’s esophagus: a question of zinc?
  Dis Esophagus. 2010. dec 17
• Hazen AL, Diks SH, Wahle JA, Fuhler GM, Peppelenbosch MP, Kerr WG
  Major remodelling of the murine stem cell kinome following differentiation in the hematopoietic compartment.
  J Proteome Res. Aug 5;10(8):3542-50

• Henry SD, Pan Q, van der Laan LJ.
  Production of Multicopy shRNA Lentiviral Vectors for Antiviral Therapy.
  Methods Mol Biol. 2011;721:313-332.

• Hoogendijk AJ, Diks SH, van der Poll T, Peppelenbosch MP, Wieland CW.
  Kinase activity profiling of pneumococcal pneumonia.
  PLoS One. 2011 Apr 5;6(4):e18519
• Kodach LL, Jacobs RJ, Voorneveld PW, Wildenberg ME, Verspaget HW, van Wezel T, Morreau H, Hommes DW, Peppelenbosch MP, van den Brink GR, Hardwick JC.
  Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway.
  Gut. 2011 May 6. [Epub ahead of print]
• J. Kwekkeboom.
  Modulation of dendritic cells and regulatory T cells by naturally occurring antibodies.
  Chapter in: Naturally occurring antibodies (NAbs).
  Editor: H.U. Lutz. Landes Bioscience, Austin, Texas, USA.
• van de Laar L, van den Bosch A, Wierenga AT, Janssen HL, Coffer PJ, Woltman AM.
  Tight Control of STAT5 Activity Determines Human CD34-Derived Interstitial Dendritic Cell and Langerhans Cell Development.
  J Immunol. Jun 15;186(12):7016-24
• van der Laan LJ, Wang Y, Tilanus HW, Janssen HL, Pan Q.
  AAV-mediated gene therapy for liver diseases: the prime candidate for clinical application?
  Expert Opin Biol Ther. 2011 Jan 5. [Epub ahead of print]
• van Leest Y, Moroso V, Wang C, Tay SS, Cunningham E, Ilie V, Bishop A, Kwekkeboom J
  No evidence for involvement of donor NK cells in liver transplant tolerance.
  Transpl Immunol. 2011 Jan 15;24(2):138-9. .
• Liu B-S, Groothuismink ZMA, Janssen HLA, Boonstra A.
  Role for IL-10 in inducing functional impairment of monocytes upon TLR4 ligation in patients with chronic HCV infections.
  J Leukocyte Biol.Jun;89(6):981-8.
• Liu B-S, Janssen HLA, Boonstra A.
  IL-29 and IFNα differ in their ability to modulate IL-12 production by TLR-activated human macrophages, and exhibit differential regulation of the IFN{gamma}; receptor expression.
  Blood 117(8): 2385-2395.
• Lorenz A, Deutschmann M, Ahlfeld J, Prix C, Koch A, Smits R, Fodde R, Kretzschmar HA, Schüller U.
  Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors.
  Mol. Cell. Biol.
• Meunier D, Patra K, Smits R, Hägebarth A, Lüttges A, Jaussi R, Wieduwilt MJ, Quintanilla-Fend L, Himmelbauer H, Fodde R, Fundele RH.
  Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors.
  Mol Carcinog. 2011 Jan;50(1):8-15.
• Viviana Moroso,Arnold van der Meer,Hugo W. Tilanus,Geert Kazemier, Luc J. W. van der Laan, Herold J. Metselaar, Irma Joosten and Jaap Kwekkeboom
  Donor and recipient HLA/KIR genotypes do not predict liver transplantation outcome.
  Transplant International
• Qiuwei Pan, Suomi M.G. Fouraschen, Fatima S.F. Aerts-Kaya, Monique M. Verstegen, Mario Pescatori, Andrew P. Stubbs, Wilfred van IJcken, Antoine van der Sloot, Ron Smits, Jaap Kwekkeboom, Herold J. Metselaar, Geert Kazemier, Jeroen de Jonge, Hugo W. Tilanus, Gerard Wagemaker, Harry L.A. Janssen and Luc J.W. van der Laan
  Mobilization of hepatic mesenchymal stem cells from human liver grafts.
  Liver Transpl. 2011 May;17(5):596-609.

• Redford PS, Boonstra A, Read S, Pitt, J, Graham C, Stavropoulos E, Bancroft GJ, O’Garra A.
  Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung.
  Eur J Immunol. 2010. 40: 2200-2210.
  

• Sikkema AH, de Bont ES, Molema G, Dimberg A, Zwiers PJ, Diks SH, Hoving EW, Kamps WA, Peppelenbosch MP, den Dunnen WF.
  VEGFR-2 signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells.
  Neuropathol Appl Neurobiol. Jan 5.
• Tjwa ET, van Oord GW, Hegmans JP, Janssen HL, Woltman AM
  Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B.
  J Hepatol. 2011 Feb;54(2):209-18
• van Veelen W, Le NH, Helvensteijn W, Blonden L, Theeuwes M, Bakker ER, Franken PF, van Gurp L, Meijlink F, van der Valk MA, Kuipers EJ, Fodde R, Smits R.
  {beta}-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis.
  Gut. 2011 Feb 9.
• van Veelen W, Korsse SE, van de Laar L, Peppelenbosch MP.
  The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling.
  Oncogene. 2011 Jan 24.
  
• Wang Y, Jia Y, Franken P, Smits R, Ewing PC, Lydon JP, DeMayo FJ, Burger CW, Grootegoed JA, Fodde R, Blok LJ.
  Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice.
  Mol. Cell. Endocrinol.
  
• van de Winkel A, van Zoest KP, van Dekken H, Moons LM, Kuipers EJ, van der Laan LJ.
  Differential expression of the nuclear receptors farnesoid X receptor (FXR) and pregnane X receptor (PXR) for grading dysplasia in patients with Barrett's oesophagus.
  Histopathology. 2011 Jan;58(2):246-53.
• Woltman AM, Op den Brouw ML, Biesta PJ, Shi CC, Janssen HL
  Hepatitis B virus lacks immune activating capacity, but actively inhibits plasmacytoid dendritic cell function.
  PLoS One. 2011 Jan 5;6(1):e15324
• Zelinkova Z, de Haar C, de Ridder L, Pierik MJ, Kuipers EJ, Peppelenbosch MP, van der Woude CJ
  High intra-uterine exposure to infliximab following maternal anti-TNF treatment during pregnancy.
  Aliment Pharmacol Ther. 2011 Mar 1.
  

2010

• Albuquerque C, Baltazar C, Filipe B, Penha F, Pereira T, Smits R, Cravo M, Lage P, Fidalgo P, Claro I, Rodrigues P, Veiga I, Ramos JS, Fonseca I, Leitão CN, Fodde R.
  Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability.
  Genes Chromosomes Cancer. Aug;49(8):746-59 (2010)
• Al-Lahham SH, Peppelenbosch MP, Roelofsen H, Vonk RJ, Venema K.
  Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms.
  Biochim Biophys Acta. 2010;1801:1175-83
• Arends JE, Claassen MA, van den Berg CH, Nanlohy NM, van Erpecum KJ, Baak BC, Hoepelman AI, Boonstra A, van Baarle D.
  T-cell responses at baseline and during therapy with peginterferon-alpha and ribavirin are not associated with outcome in chronic hepatitis C infected patients.
  Antiviral Res. Sep;87(3):353-360 (2010)
• Bosma BM, Metselaar HJ, Gerrits JH, van Besouw NM, Mancham S, Groothuismink ZMA, Boor PPC, van der Laan LJW, Tilanus HW, Kuipers EJ, Kwekkeboom J.
  Migration of allosensitizing donor myeloid dendritic cells into recipients after liver transplantation.
  Liver Transpl Jan;16(1):12-22(2010)
  
• Claassen MA, de Knegt RJ, Tilanus HW, Janssen HL, Boonstra A.
  Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis.
  J Hepatol. Mar;52(3):315-21(2010)
• Fuhler GM, Baanstra M, Chesik D, Somasundaram R, Seckinger A, Hose D, Peppelenbosch MP, Bos NA
  Bone marrow stromal cell interaction reduces syndecan-1 expression and induces kinomic changes in myeloma cells.
  Exp Cell Res.316:1816-28(2010).
  
• Haver VG, Slart RH, Zeebregts CJ, Peppelenbosch MP, Tio RA.
  Rupture of vulnerable atherosclerotic plaques: microRNAs conducting the orchestra?
  Trends Cardiovasc Med. 2010;20:65-71
• Hoogduijn MJ, Popp FC, Grohnert A, Crop MJ, van Rhijn M, Eggenhofer E, Renner P, Reinders ME, Rabelink TJ, van der Laan LJW, Genever PG, Lange C, Durrbach A, Houtgraaf JH, Christ B, Seifert M, Shagidulin M, Donckier V, Deans R, Ringden O, Perico N, Remuzzi G, Bartholomew A, Schlitt HJ, Weimar W, Baan CC, Dahlke MH; the MISOT study group
  Advancement of Mesenchymal stem cell therapy in Solid Organ Transplantation (MISOT)
  Transplantation 90(2):124-6(2010)
• van der Laan LJ, Hudson M, McPherson S, Zondervan PE, Thomas RC, Kwekkeboom J, Lindsay AS, Burt AD, Kazemier G, Tilanus HW, Bassendine MF, Metselaar HJ.
  Results of a two-center study comparing hepatic fibrosis progression in HCV-positive liver transplant patients receiving cyclosporine or tacrolimus.
  Transplant Proc. 2010 Dec;42(10):4573-7.
• van de Laar L, van den Bosch A, van der Kooij SW, Janssen HL, Coffer PJ, van Kooten C, Woltman AM.
  A nonredundant role for canonical NF-?B in human myeloid dendritic cell development and function.
  J Immunol. 2010 Dec 15;185(12):7252-61. Epub 2010 Nov 12.
• Van de Laar L, Buitenhuis M, Wensveen FM, Janssen HLA, Coffer PJ, Woltman AM.
  Human CD34-derived myeloid dendritic cell development requires intact PI3K-PKB-mTOR signaling.
  J. Immunol. 184:6600-6611 (2010)
• Leshed A, Somasundaram R, de Haar C, van der Woude CJ, Braat H, Peppelenbosch MP.
  Role of defective autophagia and the intestinal flora in Crohn disease
  Self Nonself. 2010 Oct;1(4):323-327.
  
• Li Y, de Haar C, Chen M, Deuring J, Gerrits MM, Smits R, Xia B, Kuipers EJ, van der Woude CJ.
  Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis.
  Gut. Feb;59(2):227-35(2010)
• Moroso V, Metselaar HJ, Mancham S, Tilanus HW, Eissens D, van der Meer A, van der Laan LJW, Kuipers EJ, Joosten I, Kwekkeboom J
  Liver grafts contain a unique subset of nk cells that are transferred into the recipient after liver transplantation
  Liver Transpl. Jul;16(7):895-908 (2010)
• Pan Q, Metselaar HJ, de Ruiter P, Kwekkeboom J, Tilanus HW, Janssen HLA and van der Laan LJW
  Calcineurin Inhibitor FK506 Does Not Interfere With the Suppression of Hepatitis C Virus Infection by Interferon-a .
  Liver Transpl. Apr;16(4):520-6 (2010)
  
• Pan Q and van der Laan LJW
  Hepatitis C: New Insights and Therapeutics by RNAi.
  Book chapter in “RNA Interference and Viruses: Current Innovations and Future Trends” Edited by: Miguel Angel Martínez. Caister Academic Press ISBN978-1-904455-56-1 (2010)
• Queiroz KC, Ruela-de-Sousa RR, Fuhler GM, Aberson HL, Ferreira CV, Peppelenbosch MP, Spek CA.
  Hedgehog signaling maintains chemoresistance in myeloid leukemic cells.
  Oncogene. 2010;29:6314-22.
• Redford PS, Boonstra A, Read S, Pitt J, Graham C, Stavropoulos E, Bancroft GJ, O'Garra A.
  Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung.
  Eur J Immunol. 2010 Jun 1. [Epub ahead of print]
  
• Robanus-Maandag E, Koelink P, Breukel C, Salvatori D, Jagmohan-Changur S, Bosch C, Verspaget H, Devilee P, Fodde R, Smits R.
  A new conditional Apc mutant mouse model for colorectal cancer.
  Carcinogenesis;May;31(5):946-52 (2010).
• Ruela-de-Sousa RR, Queiroz KC, Peppelenbosch MP, Fuhler GM.
  Reversible phosphorylation in haematological malignancies: potential role for protein tyrosine phosphatases in treatment?
  Biochim Biophys Acta. 2010;1806:287-303.
• Sartori da Silva MA, Tee JM, Paridaen J, Brouwers A, Runtuwene V, Zivkovic D, Diks SH, Guardavaccaro D, Peppelenbosch MP.
  Essential role for the d-Asb11 cul5 Box domain for proper notch signaling and neural cell fate decisions in vivo.
  PLoS One. 2010;19;5:e14023
• Schneiders FL, Scheper RJ, von Blomberg BM, Woltman AM, Janssen HL, van den Eertwegh AJ, Verheul HM, de Gruijl TD, van der Vliet HJ.
  Clinical experience with ?-galactosylceramide (KRN7000) in patients with advanced cancer and chronic hepatitis B/C infection.
  Clin Immunol. 2010 Dec 17.
• Sewgobind VD, van der Laan LJW, Kho MM, Hendrikx TK, van Dam T, Tilanus HW, Ijzermans JN, Weimar W, Baan CC
  Characterization of Rabbit Anti-thymocyte Globulins-Induced CD25+ Regulatory T Cells From Cells of Patients With End-Stage Renal Disease
  Transplantation. Mar 27;89(6):655-66 (2010)
• Sewgobind V., M. Quaedackers, LJW van der Laan, R. Kraaijeveld, S. Korevaar, W. Mol, G. Chan, W. Weimar and CC Baan.
  The Jak inhibitor CP-690,550 preserves the function of CD4+CD25brightFoxP3+ regulatory T cells and inhibits effector T cells
  Am. J. Transplant.Aug;10(8):1785-95 (2010)
• Sewgobind VD, van der Laan LJW, Kho MM, Kraaijeveld R, Korevaar SS, Mol W, Weimar W, Baan CC.
  The calcineurin inhibitor tacrolimus allows the induction of functional CD4+CD25+ regulatory T cells by rabbit anti-thymocyte globulins
  Clin. Exp. Immunol. Aug;161(2):364-77 (2010)
• Stoof J, Kuipers EJ, Klaver G, van Vliet AH.
  An ABC transporter and a TonB ortholog contribute to Helicobacter mustelae nickel and cobalt acquisition
  Infect Immun. 2010 Jul 19. [Epub ahead of print]
• Stoof J, Kuipers EJ, van Vliet AH.
  Characterization of NikR-responsive promoters of urease and metal transport genes of Helicobacter mustelae.
  Biometals. 2010 Feb;23(1):145-59. Epub 2009 Nov 6.
• Tapirdamaz O, Mancham S, van der Laan LJ, Kazemier G, Thielemans K, Metselaar HJ, Kwekkeboom J.
  Detailed kinetics of the direct allo-response in human liver transplant recipients: new insights from an optimized assay.
  PLoS One. 2010 Dec 29;5(12):e14452
• Tee JM, Peppelenbosch MP.
  Anchoring skeletal muscle development and disease: the role of ankyrin repeat domain containing proteins in muscle physiology.
  Crit Rev Biochem Mol Biol. 2010;45:318-30.
• Tha-In T, Metselaar HJ, Bushell AR, Kwekkeboom J/Wood KJ(shared senior authors)
  Intravenous immunoglobulins promote skin allograft acceptance by triggering functional activation of CD4+Foxp3+ T-cells
  Transplantation. Jun 27;89(12):1446-55 (2010)
  
• Tjon SWA, Sint Nicolaas J, Kwekkeboom J, de Man RA, Kazemier G, Tilanus HW, Hansen BE, van der Laan LJW, Tha-In T, and Metselaar HJ
  Increased incidence of early de novo cancer in liver graft recipients treated with cyclosporine: an association with C2 monitoring and recipient age
  Liver Transpl. Jul;16(7):837-46. (2010)
• Woltman AM, Boonstra A, and Janssen HLA
  Dendritic Cells in Chronic Viral Hepatitis B and C: Victims or Guardian Angels?
  Gut. Jan;59(1):115-25(2010) .
  

2009

• Belzer C, Stoof J, Breijer S, Kusters JG, Kuipers EJ, van Vliet AH
  The Helicobacter hepaticus hefA gene is involved in resistance to amoxicillin.
  Helicobacter. Feb;14(1),72-9(2009)
  
• Boonstra A, van der Laan LJW, Vanwolleghem T and Janssen HLA.
  Experimental models for hepatitis C viral infection. Accepted for publication.
  Hepatology. Nov;50(5):1646-55.(2009) Review
  
• Op den Brouw ML , RS Binda, TBH Geijtenbeek, HLA Janssen and AM Woltman
  The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells
  Virology. Oct 10;393(1):84-90(2009)
• Demirkiran A, Sewgobind VD, van der Weijde J, Kok A, Baan CC, Kwekkeboom J, Tilanus HW, Metselaar HJ, van der Laan LJ.
  Coversion from calcineurin inhibitor to mycophenolate mofetil-based immunosuppression changes the frequency and phenotype of CD4+FOXP3+ regulatory cells.
  Transplantation. Apr 15;87(7),1062-8, (2009)
• Gaspar C, Franken P, Molenaar L, Breukel C, van der Valk M, Smits R, Fodde R.
  A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis.
  PLoS Genet. Jul;5(7):e1000547 (2009)
• van Kooten C, Stax AM, Woltman AM, Gelderman KA.
  The use of dexamethasone in the induction of tolerogenic dendritic cells.
  Bookchapter in Handb Exp Pharmacol. (188),233-49, (2009)
• Liu B, Woltman AM, Janssen HL, Boonstra A.
  Modulation of dendritic cell function by persistent viruses.
  J Leukoc Biol. Feb;85(2), 205-14, (2009)
• Op den Brouw ML, Binda RS, Protzer U, van Roosmalen MH, Janssen HLA, van der Molen RG, Woltman AM.
  Hepatitis B virus surface antigen impairs myeloid dendritic cell function; a possible immune escape mechanism of HBV.
  Immunology. Feb;126(2), 280-9 (2009)
• Pan Q, Henry SD, Metselaar HJ, Scholte B, Kwekkeboom J, Tilanus HW, Janssen HL, van der Laan LJ
  Combined antiviral activity of interferon-alpha and RNA interference directed against hepatitis C without affecting vector delivery and gene silencing
  J Mol Med. 2009 Apr 30. [Epub ahead of print]
• Pan Q, Tilanus HW, Janssen HL, van der Laan LJ
  Prospects of RNAi and microRNA-based therapies for hepatitis C
  Expert Opin Biol Ther. Jun;9(6),713-24, (2009)
• Roth S, Franken P, van Veelen W, Blonden L, Raghoebir L, Beverloo B, van Drunen E, Kuipers EJ, Rottier R, Fodde R, Smits R
  Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology.
  Genesis. Jan;47(1),7-13, (2009)
• Sewgobind VD, Kho MM, van der Laan LJ, Hendrikx TK, van Dam T, Tilanus HW, Ijzermans JN, Weimar W, Baan CC.
  The effect of rabbit anti-thymocyte globulin induction therapy on regulatory T cells in kidney transplant patients.
  Nephrol Dial Transplant. May;24(5), 1635-44 (2009)
  
• Woltman AM, ter Borg MJ, Binda RS, Sprengers D, von Blomberg BME, Scheper RJ, Hayashi K, Nishi N, Boonstra A, Molen R and Janssen HLA
  á-Galactosylceramide in chronic hepatitis B infection: results from a randomized placebo controlled phase I/II trial
  Antivir Ther;14(6):809-18(2009)

2008

• Bosma B, Metselaar H, Nagtzaam N, de Haan R, Mancham S, van der Laan L, Kuipers E, Kwekkeboom J
  Dexamethasone transforms LPS-stimulated human blood myeloid dendritic cells (MDC) into MDC that prime IL-10 production in T-cells
  Immunology. Sep;125(1),91-100, (2008)
• Boonstra A, Woltman AM, Janssen HL.
  Immunology of hepatitis B and hepatitis C virus infections.
  Best Pract Res Clin Gastroenterol. 2008;22(6):1049-61
• Op den Brouw ML, de Jong MA, Ludwig IS, van der Molen RG, Janssen HL, Geijtenbeek TB, Woltman AM.
  Branched oligosaccharide structures on HBV prevent interaction with both DC-SIGN and L-SIGN.
  J Viral Hepat. Sep;15(9), 675-83, (2008)
• Capello A, Moons LM, Van de Winkel A, Siersema PD, van Dekken H, Kuipers EJ, Kusters JG.
  Bile acid-stimulated expression of the farnesoid X receptor enhances the immune response in Barrett esophagus.
  Am J Gastroenterol. 103(6),1510-1516, (2008)
• Demirkiran A,Hendrix T,Baan CC,van der Laan LJW.
  Impact of immunosuppressive drugs on CD4+CD25+FOXP3+ regulatory T cells: Does in vitro evidence translate to the clinical setting?
  Transplantation. 85(6),783-789, (2008)
• de Jonge PJ, Siersema PD, van Breda SG, van Zoest KP, Bac DJ, Leeuwenburgh I, Ouwendijk RJ, van Dekken H, Kusters JG, Kuipers EJ.
  Proton pump inhibitor therapy in gastro-oesophageal reflux disease decreases the oesophageal immune response but does not reduce the formation of DNA adducts.
  Aliment Pharmacol Ther. Jul 28(1),127-36 (2008)
• de Jonge PJ, van Eijck BC, Geldof H, Bekkering FC, Kuipers EJ, Siersema PD.
  Capsule endoscopy for the detection of esophageal mucosal disorders: a comparison of two different ingestion protocols.
  Scandinavian Journal of Gastroenterology.43(7),870-7,(2008)
• Henry S.D., P.G. van der Wegen, H.J. Metselaar, B.J. Scholte, H.W. Tilanus and L.J.W. van der Laan
  Hydroxyethyl starch based preservation solutions enhance gene therapy vector delivery under hypothermic conditions.
  Liver Transpl. 14(12):1708-17. (2008)
  
• Kerkhof M, Steyerberg EW, Kusters JG, van Dekken H, van Vuuren AJ, Kuipers EJ, Siersema PD.
  Aneuploidy and high expression of p53 and Ki67 is associated with neoplastic progression in Barrett esophagus.
  Cancer Biomark. 4(1):1-10 (2008)
• Moons LM, Kusters JG, van Delft JH, Kuipers EJ, Gottschalk R, Geldof H, Bode WA, Stoof J, van Vliet AH, Ketelslegers HB, Kleinjans JC, Siersema PD.
  A pro-inflammatory genotype predisposes to Barrett's esophagus.
  Carcinogenesis. May;29(5), 926-31, (2008)
• Sewgobind VD, van der Laan LJ, Klepper M, Ijzermans JN, Tilanus HW, Weimar W, Baan CC.
  Functional analysis of CD4(+) CD25(bright) T cells in kidney transplant patients: improving suppression of donor-directed responses after transplantation.
  Clin Transplant. Sep-Oct; 22(5) (2008)
• Stoof J, Breijer S, Pot RGJ, van der Neut D, Kuipers EJ, Kusters JG, van Vliet AHM.
  Inverse nickel-responsive regulation of two urease enzymes in the gastric pathogen Helicobacter mustelae.
  Environ Microbiol. Oct;10(10), 2586-97 (2008)
• Jeroen Stoof, Clara Belzer and Arnoud H.M. van Vliet
  Chapter 8 Metal metabolism and transport in Helicobacter pylori
  In Yoshio Yamaoka, Helicobacter pylori Molecular Genetics and Cellular Biology july 2008
  
• Jeroen N Stoop, Mark Claassen, Andrea M Woltman, Rekha S Binda, Ernst J Kuipers, Harry L Janssen, Renate G van der Molen, Andre Boonstra.
  Intrahepatic regulatory T cells are phenotypically distinct from their peripheral counterparts in chronic HBV patients.
  Clinical Immunology 129(3):419-27 Dec (2008)
  
• Tha-In, T., J. Bayry, H. J. Metselaar, S. V. Kaveri, and J. Kwekkeboom.
  Modulation of the cellular immune system by intravenous immunoglobulin.
  Trends in immunology 29:608-615 (2008)
• de Vries AC, van Driel HF, Richardus JH, Ouwendijk M, van Vuuren AJ, de Man RA, Kuipers EJ.
  Migrant communities constitute a possible target population for primary prevention of Helicobacter pylori-related complications in low incidence countries.
  Scand J Gastroenterol. 43(4),403-409, (2008)
• de Vries AC, van Grieken NC, Looman CW, Casparie MK, de Vries E, Meijer GA, Kuipers EJ.
  Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands.
  Gastroenterology. 134(4),945-952, (2008)
• Watashi K, Metselaar HJ, van der Laan LJW.
  Interfering with Interferon: Re-igniting the Debate on Calcineurin Inhibitor Choice and Antiviral Therapy for HCV Recurrence.
  Liver Transpl. 14(3),265-267, (2008)

2007

• Bax DA, Siersema PD, Moons LMG, van Dekken H, Tilanus HW, Kusters JG, Kuipers EJ
  CDX2 expression in columnar metaplasia of the remnant esophagus in patients who underwent esophagectomy.
  J. Clin. Gastroenterol. 41, 375-379 (2007)
• Bax DA, Siersema PD, Haringsma J, Kuipers EJ, Vos AJM, van Dekken H, van Vliet AHM, Kusters JG
  High-grade dysplasia in Barrett’s esophagus is associated with increased expression of calgranulin A and B
  Scand. J. Gastroenterol., 42, 902-910 (2007)
• Belzer C, van Schendel BAM, Kuipers EJ, Kusters JG, van Vliet AHM
  Iron-repression of urease expression in Helicobacter hepaticus is mediated by the transcriptional regulator Fur.
  Infect. Immun. 75, 745-752 (2007)
• Belzer C, Stoof J, van Vliet AHM
  Metal-responsive gene regulation and metal transport in Helicobacter species
  Biometals, 20:417-429 (2007)
• Bosma BM, Metselaar HJ, Tra W, Mancham S, Kuipers EJ, Tilanus HW, Kwekkeboom J.
  Impairment of circulating myeloid dendritic cells in immuno-suppressed liver transplant recipients.
  Clinical and Experimental Immunology, 149,525-534 (2007)
  
• Demirkiran A, Baan CC, Kok A, Metselaar HJ, Tilanus HW, van der Laan LJW
  Intrahepatic detection of FOXP3 gene expression after liver transplantation using minimally invasive aspiration biopsy
  Transplantation 83, 819-823 (2007)
• de Jonge PJF, Wolters LMM, Steyerberg EW, van Dekken H, Kusters JG, Kuipers EJ, Siersema PD
  Environmental risk factors in the development of adenocarcinoma of the esophagus or gastric cardia: a cross-sectional study in a Dutch cohort.
  Aliment. Pharmacol. Ther.,26:31-39 (2007)
• Demirkiran A, Bosma BM, Kok A, Baan CC , Metselaar HJ, IJzermans JNM , Tilanus HW, Kwekkeboom J and van der Laan LJW
  Allo-suppressive donor CD4+CD25+ regulatory T cells detach from the graft and circulate in recipients after liver transplantation.
  J. Immunol. 178: 6066-72 (2007)
  
• Dierikx CM, Martodihardjo J, Kuipers EJ, Hensgens CMH, Kusters JG, Suzuki H, de Groot N, van Vliet AHM
  Serum- and Animal Tissue-Free Medium (SATFM) for transport and growth of Helicobacter pylori
  FEMS Immunol. Med. Microbiol., 50(2):239-43 (2007)
• Ernst FD, van Vliet AHM, Kist M, Kusters JG, Berenswill S.
  The role of nickel in environmental adaptation of the gastric pathogen Helicobacter pylori
  In Sigel A, Sigel H, Sigel RKO (Eds) Metal Ions Life Sci., vol 2, Nickel and Its Surprising Impact in Nature.
  John Wiley & Sons Ltd, Bognor Regis, West Sussex, Uk. 545-580 (2007)
• Gerrits MM, van Vliet AHM, Kuipers EJ, Kusters JG.
  Klinische implicatie en moleculaire mechanismen van antibioticumresistentie by Helicobacter pylori .
  Ned. Tijdschr. Med. Microbiol. 15 (2), 66-72 (2007)
  
• Godoy A, Reis F, Ferraz L, Gerrits MM, Mendonca S, Kusters JG, Ottoboni L, Ribeiro M, Pedrazzoli J
  Differentially expressed genes in response to amoxicillin in Helicobacter pylori analyzed by RNA arbitrarily primed PCR
  FEMS Immunol. Med. Microbiol., 50, 226-230 (2007)
• Kerkhof M, Steyerberg EW, Kusters JG, Kuipers EJ, Siersema PD.
  Predicting presence of intestinal metaplasia and dysplasia in columnar-lined esophagus: a multivariate analysis.
  Endoscopy. 39,772-778 (2007)
• Kerkhof M, van Dekken H, Steyerberg EW, Meijer GA, Mulder AH, de Bruïne A, Driessen A, ten Kate FJ, Kusters JG, Kuipers EJ, Siersema PD; CYBAR study group.
  Grading of dysplasia in Barrett's oesophagus: substantial interobserver variation between general and gastrointestinal pathologists.
  Histopathology. 50,920-927 (2007)
• Kerkhof M, Kusters JG, van Dekken H, Kuipers EJ, Siersema PD.
  Biomarkers for risk stratification of neoplastic progression in Barrett esophagus.
  Cell Oncol. 29(6),507-17 (2007)
• van der Laan LJW / Wolach B [shared first authors], Maianski NA , Tool AT, van Bruggen R, Roos D and Kuijpers TW
  Growth factors G-CSF and GM-CSF differentially preserve chemotaxis of neutrophils aging in vitro.
  Exp. Hematol. 35:541-50 (2007)
• van der Laan LJ, Taimr P, Kok A, Sprengers D, Zondervan PE, Tilanus HW, Janssen HL.
  Flowcytometric quantitation of hepatitis B viral antigens in hepatocytes from regular and fine-needle biopsies.
  J. J. Virol. Methods 142: 189-197 (2007)
  
• Henry SD, Metselaar HJ, van Dijck J, Tilanus HW and van der Laan LJW.
  Impact of steroids on hepatitis C virus replication in vivo and in vitro.
  Ann N Y Acad. Sci., 1110:439-447 (2007)
• Moons LMG, Kuipers EJ, Rygiel AM, Groothuismink ZMA, Geldof H, Bode WA, Krishnadath KA, Bergman JJGHM, van Vliet AHM, Siersema PD, Kusters JG.
  COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinoma
  Am. J. Gastroenterol., 102:2373-2379
• O Croinin T, McCormack A, van Vliet AHM, Kusters JG, Bourke B.
  Random mutagenesis to identify novel Helicobacter mustelae virulence factors
  FEMS Immunol. Med. Microbiol., 50(2):257-63 (2007)
• Pan Q, Henry SD, Scholte BJ,Tilanus HW, Janssen HLA and van der Laan LJW.
  New therapeutic opportunities for Hepatitis C based on small RNA.
  World J. Gastroenterol., 13(33):4431-6 (2007)
• Pot RGJ, Stoof J, Nuijten PJM, de Haan LAM, Loeffen P, Kuipers EJ, van Vliet AHM, Kusters JG.
  UreA2B2: a second urease system in the gastric pathogen Helicobacter felis
  FEMS Immunol. Med. Microbiol., 50(2):273-9 (2007)
• Sprengers D, van der Molen RG, Binda R, Kusters JG, de Man RA, Niesters HGM, Schalm SW, Janssen HLA.
  In vivo immunization in combination with peg-interferon for chronic hepatitis B virus infection
  J. Viral Hepat., 14:743-749 (2007)
• Sprengers D, Stoop JN, Binda RS, Kusters JG, Haagmans BL, Carotenuto P, Artsen A, van der Molen RG, Janssen HL.
  Induction of regulatory T-cells and interleukin-10-producing cells in non-responders to pegylated interferon-alpha therapy for chronic hepatitis B.
  Antivir Ther. 12(7):1087-96 (2007)
• Stoop JN, van der Molen RG, Kuipers EJ, Kusters JG, Janssen HLA.
  Inhibition of viral replication reduces regulatory T cells and enhances the antiviral immune response in chronic hepatitis B
  Virology, 361:141-148 (2007)
• Stoop JN, Woltman AM, Biesta PJ, Kusters JG, Kuipers EJ, Janssen HLA, van der Molen RG.
  Tumor necrosis factor alpha inhibits the suppressive effect of regulatory T cells on the hepatitis B virus-specific immune response
  Hepatology. 25; 46:699-705 (2007)
• Tha-In T, Luo S, Bushell AR, Wood KJ.
  Functional dichotomy of NK cells in organ transplantation
  Exp. Rev. Clin. Immunol. 3, 261-266 (2007)
• Tha-In T, Metselaar HJ, Tilanus HW, Groothuismink ZMA, Kuipers EJ, de Man RA, Kwekkeboom J.
  Intravenous immunoglobulins suppress T-cell priming by modulating the bi-directional interaction between Dendritic Cells and Natural Killer cells.
  Blood.,110:3253-3262 (2007)
• de Vries AC, Haringsma J, Kuipers EJ.
  The detection, surveillance and treatment of pre-malignant gastric lesions related to Helicobacter pylori infection
  Helicobacter 12, 1-15 (2007)
• de Vries AC, Meijer GA, Looman CW, Casparie MK, Hansen BE, van Grieken NC, Kuipers EJ.
  Epidemiological trends of pre-malignant gastric lesions: a long-term nationwide study in the Netherlands.
  Gut. 2007,1665-70 (2007)
• de Vries AC, Kuipers EJ.
  Review article: Helicobacter pylori eradication for the prevention of gastric cancer.
  Aliment Pharmacol Ther, Suppl 2:25-35 (2007)
• de Vries AC, Kuipers EJ.
  Epidemiology of premalignant gastric lesions: implications for the development of screening and surveillance strategies.
  Helicobacter,12 Suppl 2:22-31(2007)
• van Vliet AHM, Kusters JG.
  Pathogenesis and Host Response in Helicobacter infections
  FEMS Immunology & Medical Microbiology 50 (2), 145–145 (2007)

2006

• van Amsterdam K, van Vliet AHM, Kusters JG, van der Ende A
  Of microbe and man: determinants of Helicobacter pylori-related diseases
  FEMS Microbiol. Rev. 30, 131-156 (2006)
• Belzer C, Kusters JG, Kuipers EJ, van Vliet AHM
  Urease-induced calcium precipitation by Helicobacter species may initiate gallstone formation
  Gut 55, 1678-1679 (2006)
• Boor PPC, Metselaar HJ, Mancham S, Tilanus HW, Kusters JG, Kwekkeboom J
  Prednisolone suppresses the function and promotes apoptosis of plasmacytoid dendritic cells
  Am. J. Transplant. 6, 2332-2341 (2006)
• Bosma BM, Metselaar HJ, Mancham S, Boor PPC, Kusters JG, Kazemier G, Tilanus HW, Kuipers EJ, Kwekkeboom J
  Characterization of human liver dendritic cells in liver grafts and perfusates
  Liver Transplant. 12, 384-393 (2006)
• Demirkiran A, Kok A, Kwekkeboom J, Kusters JG, Metselaar HJ, Tilanus HW, van der Laan LJW
  Low circulating regulatory T cell levels after acute rejection in liver transplantation
  Liver Transplant. 12, 277-284 (2006)
• Dossumbekova A, Prinz C, Gerhard M, Brenner L, Backert S, Kusters JG, Schmid RM, Rad R
  Helicobacter pylori outer membrane proteins and gastric inflammation
  Gut 55, 1360-1361 (2006)
• Dossumbekova A, Prinz C, Mages J, Lang R, Kusters JG, van Vliet AHM, Reindl W, Backert S, Saur D, Schmid RM, Rad R
  Helicobacter pylori HopH (OipA) and bacterial pathogenicity: Genetic and functional genomic analysis of hopH gene polymorphisms
  J. Infect. Dis. 194, 1346-1355 (2006)
• Ernst FD, Stoof J, Horrevoets WM, Kuipers EJ, Kusters JG, van Vliet AHM
  NikR mediates nickel-responsive transcriptional repression of the Helicobacter pylori outer membrane proteins FecA3 (HP1400) and FrpB4 (HP1512)
  Infect. Immun. 74, 6821-6828 (2006)
• Gerrits MM
  Antibioticumresistentie in Helicobacter pylori
  Analyse 61, 72-75 (2006)
• Gerrits MM, Godoy APO, Kuipers EJ, Ribeiro ML, Stoof J, Mendonca S, van Vliet AHM, Pedrazzoli J, Kusters JG
  Multiple mutational changes in the pbp1A gene mediate amoxicillin resistance in Helicobacter pylori
  Helicobacter 11, 181-187 (2006)
• Gerrits MM, van Vliet AHM, Kuipers EJ, Kusters JG
  Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications
  Lancet Infect. Dis. 6, 699-709 (2006)
• Henry SD, Metselaar HJ, Lonsdale RCB, Kok A, Haagmans BL, Tilanus HW, van der Laan LJW
  Mycophenolic acid inhibits hepatitis C virus replication and acts in synergy with cyclosporin A and interferon-alpha
  Gastroenterology 131, 1452-1462 (2006)
• Henry S, van der Wegen P, Metselaar H, Tilanus H, Scholte B, van der Laan LJW
  Simultaneous targeting of HCV replication and viral entry with a single vector containing multiple RNA interference expression cassettes
  Mol. Ther. 14, 485-493 (2006)
• de Jonge PJF, Steyerberg EW, Kuipers EJ, Honkoop P, Wolters LMM, Kerkhof M, van Dekken H, Siersema PD
  Risk factors for the development of esophageal adenocarcinoma in Barrett's esophagus.
  Am. J. Gastroenterol., 101, 1421-1429 (2006)
• Kerkhof M, Bax DA, Moons LMG, van Vuuren AJ, van Dekken H, Steyerberg EW, Kuipers EJ, Kusters JG, Siersema PD, for the CYBAR study group
  Does CDX2 expression predict Barrett’s metaplasia in oesophageal columnar epithelium without goblet cells?
  Aliment. Pharmacol. Ther. 24, 1613-1621 (2006)
• Kruijshaar ME, Kerkhof M, Siersema PD, Steyerberg EW, Homs MY, Essink-Bot ML, for the CYBAR Study Group
  The burden of upper gastrointestinal endoscopy in patients with Barrett's esophagus.
  Endoscopy 38, 873-878 (2006)
• Kusters JG, van Vliet AHM, Kuipers EJ
  Pathogenesis of Helicobacter pylori infection
  Clin. Microbiol. Rev. 19, 449-490 (2006)
• van der Molen RG, Sprengers D, Biesta PJ, Kusters JG, Janssen HLA
  Favorable Effect of Adefovir Treatment on the Number and Functionality of Myeloid Dendritic Cells of Chronic HBV Patients
  Hepatology 44, 907-914 (2006)
• Ridder L, van Dieren JM, Van Deventer HJ, Stokkers PC, Van der Woude JC, van Vuuren AJ, Benninga MA, Escher JC, Hommes DW
  Pharmacogenetics of thiopurine therapy in paediatric IBD patients.
  Aliment. Pharmacol. Ther. 23, 1137-1141 (2006)
  
• Sital RR, Kusters JG, De Rooij FW, Kuipers EJ, Siersema PD
  Bile acids and Barrett's oesophagus: A sine qua non or coincidence?
  Scand. J. Gastroenterol. 243 (Suppl), 11-17 (2006)
  
• Sprengers D, van der Molen RG, Kusters JG, Hansen B, Niesters HG, Schalm SW, Janssen HL
  Different composition of intrahepatic lymphocytes in the immune-tolerance and immune-clearance phase of chronic hepatitis B.
  J. Med. Virol. 78, 561-568 (2006)
  
• Sprengers D, van der Molen RG, Kusters JG, de Man RA, Niesters HGM, Schalm SW, Janssen HLA
  Persistence of intrahepatic HBV-specific cytotoxic T lymphocytes after resolution of acute hepatitis B virus infection in humans
  J. Hepatol., 45, 182-9 (2006)
• Stähler FN, Odenbreit S, Haas R, Wilrich J, van Vliet AHM, Kusters JG, Kist M, Bereswill S
  The novel Helicobacter pylori CznABC metal efflux pump is required for cadmium, zinc and nickel resistance, for urease modulation and for gastric colonization
  Infect. Immun. 74, 3845-3852 (2006)
  
• Stoop JN, Janssen HLA, van der Molen RG
  Immune regulation during a chronic HBV infection.
  Shelter 1, 3-7 (2006)
• Tang TJ, Vukosavljevic D, Janssen HLA, Binda RS, Mancham S, Tilanus HW, IJzermans JNM, Drexhage H, Kwekkeboom J
  Aberrant composition of the dendritic cell population in hepatic lymph nodes of patients with hepatocellular carcinoma
  Hum. Pathol. 37, 332-338 (2006)
• Tapirdamaz O, Pravica V, Metselaar HJ, Hansen B, Moons LMG, van Meurs JB, Hutchinson IV, Shaw J, Agarwal K, Adams DH, Day CP, Kwekkeboom J
  Polymorphisms in the T-cell regulatory gene CTLA-4 influence the rate of acute rejection after liver transplantation
  Gut 55, 863-868 (2006)
• Tha-In T, Metselaar HJ, Tilanus HW, Boor PPC, Mancham S, Kuipers EJ, de Man RA, Kwekkeboom J
  Superior immunomodulatory effects of intravenous immunoglobulins on human T-cells and dendritic cells: Comparison to calcineurin inhibitors.
  Transplantation 81, 1725-1734 (2006)

2005

• Bax DA, Siersema PD, van Vliet AHM, Kuipers EJ, Kusters JG
  Molecular alterations during development of esophageal adenocarcinoma
  J. Surg. Oncol. 92, 89-98 (2005)
• Bax DA
  Barrett's esophagus: a molecular characterization
  PhD thesis, Erasmus Universiteit Rotterdam (2005) (ISBN 90-8559-101-5)
• Belzer C, Stoof J, Beckwith CS, Kuipers EJ, Kusters JG, van Vliet AHM
  Differential regulation of urease activity in Helicobacter hepaticus and Helicobacter pylori
  Microbiology 151, 3989-3995 (2005)
• Bereswill S, Schonenberger R, van Vliet AHM, Kusters JG, Kist M
  Novel plasmids for gene expression analysis and for genetic manipulation in the gastric pathogen Helicobacter pylori
  FEMS Immunol. Med. Microbiol. 44, 157-162 (2005)
  
• Boomkens SY, de Rave S, Pot RGJ, Egberink HF, Penning LC, Rothuizen J, Zondervan PR, Kusters JG
  The role of Helicobacter spp. in the pathogenesis of primary biliary cirrhosis and primary sclerosing cholangitis
  FEMS Immunol. Med. Microbiol. 44, 221-225 (2005)
• Boor PPC, IJzermans JN, van der Molen RG, Binda RS, Mancham S, Metselaar HJ, Kusters JG, de Jong E, Drexhage HA, Kwekkeboom J
  Immunomagnetic selection of functional dendritic cells from human lymph nodes
  Immunol. Lett. 99, 162-168 (2005)
• Briedé JJ, Pot RGJ, Kuipers EJ, van Vliet AHM, Kleinjans JCS, Kusters JG
  The presence of the cag pathogenicity island is associated with increased superoxide anion radical scavenging activity by Helicobacter pylori
  FEMS Immunol. Med. Microbiol. 44, 227-232 (2005)
  
• Brisslert M, Enarsson K, Lundin S, Karlsson A, Kusters JG, Svennerholm AM, Backert S, Quiding-Jarbrink M
  Helicobacter pylori induce neutrophil transendothelial migration: Role of the bacterial HP-NAP.
  FEMS Microbiol Lett. 249, 95-103 (2005)
  
• Demirkiran A, Kok A, Kwekkeboom J, Metselaar HJ, Tilanus HW, van der Laan LJW
  Decrease of CD4(+)CD25(+) T cells in peripheral blood after liver transplantation: Association with immunosuppression
  Transplant Proc. 37, 1194-1196 (2005)
• van Dieren JM, van Vuuren AJ, Kusters JG, Nieuwenhuis EE, Kuipers EJ, van der Woude CJ
  ITPA genotyping is not predictive for the development of side effects in AZA treated inflammatory bowel disease patients.
  Gut 54, 1664 (2005)
• Ernst FD, Bereswill S, Waidner B, Stoof J, Mäder U, Kusters JG, Kuipers EJ, Kist M, van Vliet AHM, Homuth G
  Transcriptional profiling of Helicobacter pylori Fur- and iron-regulated gene expression
  Microbiology 151, 533-546 (2005)
• Ernst FD, Homuth G, Stoof J, Mäder U, Waidner B, Kuipers EJ, Kist M, Kusters JG, Bereswill S, van Vliet AHM
  Iron-responsive regulation of the Helicobacter pylori iron-cofactored superoxide dismutase SodB is mediated by Fur
  J. Bacteriol. 187, 3687-3692 (2005)
• Ernst FD, Kuipers EJ, Heijens A, Sarwari R, Stoof J, Penn CW, Kusters JG, van Vliet AHM
  The nickel-responsive regulator NikR controls activation and repression of gene transcription in Helicobacter pylori
  Infect. Immun. 73, 7252-7258 (2005)
• Ernst FD
  Transcriptional regulation of the nickel and iron metabolism in Helicobacter pylori
  PhD thesis, Erasmus Universiteit Rotterdam (2005) (ISBN 90-8559-097-3)
• Flink HJ, Sprengers D, Hansen BE, van Zonneveld M, Verhey E, de Man RA, Schalm SW, Janssen HLA
  Flares in chronic hepatitis B patients induced by the host or the virus? Relation to treatment response during Peg-interferon {alpha}-2b therapy.
  Gut 54, 1604-1609 (2005)
  
• Glocker E, Berning M, Gerrits MM, Kusters JG, Kist M
  Real-time PCR screening for 16S rRNA mutations associated with resistance to tetracycline in Helicobacter pylori
  Antimicrob. Agents Chemother. 49, 3166-3170 (2005)
• Gorrell RJ, Yanga J, Kusters JG, van Vliet AHM, Robins-Browne RM
  Restriction of DNA encoding selectable markers undermines the transformation efficiency of Helicobacter pylori
  FEMS Immunol. Med. Microbiol. 44, 213-219 (2005)
• Krogfelt KA, Andersen LP, Kusters JG
  Pathogenesis and host response in Helicobacter infections (Editorial)
  FEMS Immunol. Med. Microbiol. 44, 111 (2005)
  
• Kwekkeboom J, Boor PPC, Sen E, Kusters JG, Drexhage HA, de Jong EC, Tilanus HW, IJzermans JNM, Metselaar HJ
  Human liver myeloid dendritic cells maturate in vivo into effector DC with a poor allogeneic T-cell stimulatory capacity
  Transplant. Proc. 37, 15-16 (2005)
• Kwekkeboom J, Tha-In T, Tra WMW, Hop W, Boor PPC, Mancham S, Zondervan PE, Vossen ACTM, Kusters JG, de Man RA, Metselaar HJ
  Hepatitis B immunoglobulins inhibit dendritic cells and T-cells and protect against acute rejection after liver transplantation
  Am. J. Transpl. 5, 2393-2402 (2005)
• Moons LMG, Kusters JG, Bultman E, Kuipers EJ, van Dekken H, Tra WMW, Kleinjan A, Kwekkeboom J, van Vliet AHM, Siersema PD
  Barrett’s oesophagus is characterised by a predominant humoral inflammatory response
  J. Pathol. 207, 269-276 (2005)
• Moons LMG, Siersema PD, Kuipers EJ, van Vliet AHM, Kusters JG
  IL-1RN polymorphism is not associated with Barrett’s esophagus and esophageal adenocarcinoma
  Am. J. Gastroenterol. 100, 2818 (2005)
• Sprengers D, Janssen HLA
  Immunomodulatory therapy for chronic hepatitis B virus infection
  Fundam. Clin. Pharmacol. 19, 17-26 (2005)
• Sprengers D, van der Molen RG, Kusters JG, Kwekkeboom J, van der Laan LJW, Niesters HGM, Kuipers EJ, De Man RA, Schalm SW, Janssen HLA
  Flow cytometry of fine-needle-aspiration-biopsies: a new method to monitor intrahepatic immunological environment in chronic viral hepatitis.
  J. Viral. Hepat. 12, 507-512 (2005)
• Stoop JN, Van der Molen RG, Baan CC, Van der Laan LJW, Kuipers EJ, Kusters JG, Janssen HLA
  Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
  Hepatology 41, 771-778 (2005)
• Tang TJ, Kwekkeboom J, Mancham S, Binda RS, de Man RA, Schalm SW, Kusters JG, Janssen HLA
  Intrahepatic CD8+ T-lymphocyte response is important for therapy-induced viral clearance in chronic hepatitis B infection
  J. Hepatol. 43, 45-52 (2005)
• Tha-In T, Hesselink DA, Tilanus HW, Elshove L, Wilschut AL, Hansen BE, van Gelder T, Metselaar HJ
  Clinical outcome after cyclosporine dose reduction based on C2 levels in long term liver transplant patients
  Clin. Transpl. 19, 537-542 (2005)
• Warle MC, van der Laan LJW, Kusters JG, Pot RGJ, Hop WC, Segeren KCA, IJzermans JNM, Metselaar HJ, Tilanus HW
  TNF-alpha gene polymorphism and production among inbred rat strains with short- and long-term liver allograft survival
  Transpl. Immunol. 14, 77-82 (2005)
• Warle MC, Metselaar HJ, Kusters JG, Zondervan PE, Hop WC, Segeren KC, Kwekkeboom J, IJzermans JN, Tilanus HW
  Strain-specific in vitro cytokine production profiles do not predict rat liver allograft survival
  Transpl. Int. 17, 779-786 (2005)
• West RL, Van der Woude CJ, Endtz HP, Hansen BE, Ouwedijk M, Boelens HA, Kusters JG, Kuipers EJ
  Perianal fistulas in Crohn's disease are predominantly colonized by skin flora: implications for antibiotic treatment?
  Dig Dis Sci. 50, 1260-1263 (2005)
• Wooldridge KG, van Vliet AHM
  Iron Transport and Regulation
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