Inflammatory bowel disease and colorectal cancer

Researchers involved

     

 


C.J. v.d. Woude
(Janneke) MD,PhD,
Work group leader

Z. Zelinkova
(Zuzana) MD,PhD,
Work group leader

Y. Li,
(Yi) MD,
PhD student

J. Deuring
(Jasper), BSc,
technician


H.J. Verhoog
(Hans), BSc,
technician

 
 

Colorectal cancer is the most common cancer in the gastrointestinal tract and the second most frequent cause of cancer-related death in the West. Despite the relatively high number of cases and death, the exact nature of colorectal cancer is still unknown. Our current research is focussed on the molecular and immunological aspects of colorectal cancer-related neoplastic progression.

The main research lines are:
- Detection of prognostic parameters in colon epithelium that can predict if malignancy will develop.
- Screening of high-risk patients (e.g. history of polyps, history of inflammatory bowel disease, family history of colorectal cancer) using biomarker-based flowcytometry.
- Characterization of pathways that initiate and/or maintain colorectal cancer-related neoplastic progression.

 

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